Inflammation-induced IL-6 functions as a natural brake on macrophages and limits GN
M Luig, MA Kluger, B Goerke, M Meyer… - Journal of the …, 2015 - journals.lww.com
IL-6 can mediate proinflammatory effects, and IL-6 receptor (IL-6R) blockade as a treatment
for inflammatory diseases has entered clinical practice. However, opposing effects of IL-6
have been observed in models of GN. Although IL-6 is proinflammatory in murine lupus
nephritis, protective effects have been observed for IL-6 in the nephrotoxic nephritis (NTN)
model of acute crescentic GN. In light of the potential dangers of IL-6–directed treatment, we
studied the mechanisms underlying the contradictory findings in GN. IL-6 can signal through …
for inflammatory diseases has entered clinical practice. However, opposing effects of IL-6
have been observed in models of GN. Although IL-6 is proinflammatory in murine lupus
nephritis, protective effects have been observed for IL-6 in the nephrotoxic nephritis (NTN)
model of acute crescentic GN. In light of the potential dangers of IL-6–directed treatment, we
studied the mechanisms underlying the contradictory findings in GN. IL-6 can signal through …