TNF-α deficiency accelerates renal tubular interstitial fibrosis in the late stage of ureteral obstruction
Y Morimoto, Z Gai, H Tanishima, M Kawakatsu… - … and molecular pathology, 2008 - Elsevier
TNF-α and TGF-β1 have a complementary relationship in fibrogenesis. This study was
performed to investigate the role of TNF-α in renal tubular interstitial fibrosis. We compared
the extent of renal tubular interstitial fibrosis after unilateral ureteral obstruction (UUO)
between wild-type and TNF-α-deficient mice by using immunohistochemistry, enzyme-linked
immunoassay, and the real-time polymerase chain reaction (PCR). In comparison with wild-
type mice, there was no significant difference in the extent of renal fibrosis in the TNF-α …
performed to investigate the role of TNF-α in renal tubular interstitial fibrosis. We compared
the extent of renal tubular interstitial fibrosis after unilateral ureteral obstruction (UUO)
between wild-type and TNF-α-deficient mice by using immunohistochemistry, enzyme-linked
immunoassay, and the real-time polymerase chain reaction (PCR). In comparison with wild-
type mice, there was no significant difference in the extent of renal fibrosis in the TNF-α …