Fatty acid amides constitute a large and diverse class of lipid transmitters that includes the
endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. The
magnitude and duration of fatty acid amide signaling are controlled by enzymatic hydrolysis
in vivo. Fatty acid amide hydrolase (FAAH) activity in mammals has been primarily attributed
to a single integral membrane enzyme of the amidase signature (AS) family. Here, we report
the functional proteomic discovery of a second membrane-associated AS enzyme in …