The T3-induced gene KLF9 regulates oligodendrocyte differentiation and myelin regeneration
JC Dugas, A Ibrahim, BA Barres - Molecular and Cellular Neuroscience, 2012 - Elsevier
Hypothyroidism is a well-described cause of hypomyelination. In addition, thyroid hormone
(T3) has recently been shown to enhance remyelination in various animal models of CNS
demyelination. What are the ways in which T3 promotes the development and regeneration
of healthy myelin? To begin to understand the mechanisms by which T3 drives myelination,
we have identified genes regulated specifically by T3 in purified oligodendrocyte precursor
cells (OPCs). Among the genes identified by genomic expression analyses were four …
(T3) has recently been shown to enhance remyelination in various animal models of CNS
demyelination. What are the ways in which T3 promotes the development and regeneration
of healthy myelin? To begin to understand the mechanisms by which T3 drives myelination,
we have identified genes regulated specifically by T3 in purified oligodendrocyte precursor
cells (OPCs). Among the genes identified by genomic expression analyses were four …