Transforming growth factor-β inhibits surfactant protein A expression in vitro
JA Whitsett, A Budden, WM Hull, JC Clark… - … et Biophysica Acta (BBA …, 1992 - Elsevier
Abstract Effects of members of the transforming growth factor-β (TGF-β) family on expression
of surfactant protein A (SP-A) were determined in human pulmonary adenocarcinoma cells.
TGF-β decreased SP-A content in two distinct pulmonary adenocarcinoma cell lines with
bronchiolar (NCI-H441-4) and alveolar (NCI-H820) cell characteristics. TGF-β 1, β 2 and β 3
were equally effective in decreasing SP-A. Effects of the TGF-β's on SP-A content were dose
dependent, EC 50 approximately 20–30 pg/ml for each form of TGF-β. TGF-β decreased …
of surfactant protein A (SP-A) were determined in human pulmonary adenocarcinoma cells.
TGF-β decreased SP-A content in two distinct pulmonary adenocarcinoma cell lines with
bronchiolar (NCI-H441-4) and alveolar (NCI-H820) cell characteristics. TGF-β 1, β 2 and β 3
were equally effective in decreasing SP-A. Effects of the TGF-β's on SP-A content were dose
dependent, EC 50 approximately 20–30 pg/ml for each form of TGF-β. TGF-β decreased …