[HTML][HTML] Cleaning up: ER-associated degradation to the rescue
JL Brodsky - Cell, 2012 - cell.com
JL Brodsky
Cell, 2012•cell.comAll cellular proteins are subject to quality control" decisions," which help to prevent or delay
a myriad of diseases. Quality control within the secretory pathway creates a special
challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for
proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated
degradation (ERAD).
a myriad of diseases. Quality control within the secretory pathway creates a special
challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for
proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated
degradation (ERAD).
All cellular proteins are subject to quality control "decisions," which help to prevent or delay a myriad of diseases. Quality control within the secretory pathway creates a special challenge, as aberrant polypeptides are recognized and returned to the cytoplasm for proteasomal degradation. This process is termed endoplasmic-reticulum (ER)-associated degradation (ERAD).
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