Characterization of Fe2+ and Fe3+ transport by iron-loaded cardiac myocytes
JG Parkes, NF Olivieri, DM Templeton - Toxicology, 1997 - Elsevier
Plasma iron overload causes cardiac iron accumulation leading to toxicity and organ failure.
In order to understand the basis of iron acquisition, we examined mechanisms of Fe3+ and
Fe2+ uptake in control and iron-loaded cardiomyocyte cultures. Iron loading increased rates
of Fe3+ and Fe2+ uptake, primarily by increasing Vmax. Inhibition of Fe3+ transport by
impermeable Fe2+ chelators and the presence of a cell surface ferricyanide reductase
activity are consistent with a role for redox cycling in Fe3+ uptake. However, flavoproteins …
In order to understand the basis of iron acquisition, we examined mechanisms of Fe3+ and
Fe2+ uptake in control and iron-loaded cardiomyocyte cultures. Iron loading increased rates
of Fe3+ and Fe2+ uptake, primarily by increasing Vmax. Inhibition of Fe3+ transport by
impermeable Fe2+ chelators and the presence of a cell surface ferricyanide reductase
activity are consistent with a role for redox cycling in Fe3+ uptake. However, flavoproteins …