Monocytes are essential for the neuroprotective effect of human cord blood cells following middle cerebral artery occlusion in rat
TA Womble, S Green, M Shahaduzzaman… - Molecular and Cellular …, 2014 - Elsevier
Systemic administration of human umbilical cord blood (HUCB) mononuclear cells (MNC)
following middle cerebral artery occlusion (MCAO) in the rat reduces infarct size and, more
importantly, restores motor function. The HUCB cell preparation is composed of immature T-
cells, B-cells, monocytes and stem cells. In this study we examined whether the beneficial
effects of HUCB injection were attributable to one of these cell types. Male Sprague Dawley
rats underwent permanent MCAO followed 48 h later by intravenous administration of HUCB …
following middle cerebral artery occlusion (MCAO) in the rat reduces infarct size and, more
importantly, restores motor function. The HUCB cell preparation is composed of immature T-
cells, B-cells, monocytes and stem cells. In this study we examined whether the beneficial
effects of HUCB injection were attributable to one of these cell types. Male Sprague Dawley
rats underwent permanent MCAO followed 48 h later by intravenous administration of HUCB …
