[HTML][HTML] A double mutation in the extracellular Ca2+-sensing receptor's venus flytrap domain that selectively disables L-amino acid sensing
HC Mun, EL Culverston, AH Franks, CA Collyer… - Journal of Biological …, 2005 - ASBMB
The extracellular Ca 2+-sensing receptor is activated allosterically by l-amino acids, and
recent molecular analysis indicates that amino acids are likely to bind in the receptor's
Venus flytrap domain. In the current study we set out to identify residues in the VFT domain
that specifically support amino acid binding and/or amino acid-dependent receptor
activation. Herein we describe two mutations of the Ca 2+-sensing receptor (CaR) Venus
Flytrap domain, T145A and S170T, that specifically impair amino acid sensing, leaving Ca …
recent molecular analysis indicates that amino acids are likely to bind in the receptor's
Venus flytrap domain. In the current study we set out to identify residues in the VFT domain
that specifically support amino acid binding and/or amino acid-dependent receptor
activation. Herein we describe two mutations of the Ca 2+-sensing receptor (CaR) Venus
Flytrap domain, T145A and S170T, that specifically impair amino acid sensing, leaving Ca …