Anti-parathyroid and anti-calcium sensing receptor antibodies in autoimmune hypoparathyroidism
EM Brown - Endocrinology and metabolism clinics of North America, 2009 - Elsevier
The parathyroid glands are an infrequent target for autoimmunity, the exception being
autoimmune polyglandular syndrome type 1, in which autoimmune hypoparathyroidism is
the rule. Antibodies that are directed against the parathyroid cell surface calcium-sensing
receptor (CaSR) have recently been recognized to be present in the serum of patients with
autoimmune hypoparathyroidism. In some individuals, these anti-CaSR antibodies have
also been shown to produce functional activation of the receptor, suggesting a direct …
autoimmune polyglandular syndrome type 1, in which autoimmune hypoparathyroidism is
the rule. Antibodies that are directed against the parathyroid cell surface calcium-sensing
receptor (CaSR) have recently been recognized to be present in the serum of patients with
autoimmune hypoparathyroidism. In some individuals, these anti-CaSR antibodies have
also been shown to produce functional activation of the receptor, suggesting a direct …