Sequences 5′ of the bovine keratin 5 gene direct tissue-and cell-type-specific expression of a lacZ gene in the adult and during development
A Ramírez, A Bravo, JL Jorcano, M Vidal - Differentiation, 1994 - Elsevier
Expression of keratin K5 (and K14) in multilayered epithelia occurs predominantly in the
basal layer of proliferating keratinocytes. When a keratinocyte becomes committed to
terminal differentiation, it moves out of the basal layer towards the epithelial surface. As part
of this program of terminal differentiation, the expression of K5 (and K14) is downregulated
in suprabasal cells, and new pairs of differentiation-specific keratins are expressed. To
define the cis-acting DNA sequences required for K5 cell-type-and differentiation-specific …
basal layer of proliferating keratinocytes. When a keratinocyte becomes committed to
terminal differentiation, it moves out of the basal layer towards the epithelial surface. As part
of this program of terminal differentiation, the expression of K5 (and K14) is downregulated
in suprabasal cells, and new pairs of differentiation-specific keratins are expressed. To
define the cis-acting DNA sequences required for K5 cell-type-and differentiation-specific …