Sexual disparities in the incidence and course of SLE and RA
SK Tedeschi, B Bermas, KH Costenbader - Clinical Immunology, 2013 - Elsevier
Systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) disproportionately affect
females compared to males, with female to male prevalence ratios of 7–9: 1 for SLE and 2–
3: 1 for RA. Interestingly, epidemiologic studies indicate that men that develop SLE may
have more morbidity than women, but the same is not true for RA. Given the sex and age
bias of SLE and RA, sex hormones may influence the pathogenesis of these diseases.
However, the ways in which, and to what degree, sex hormones affect disease incidence …
females compared to males, with female to male prevalence ratios of 7–9: 1 for SLE and 2–
3: 1 for RA. Interestingly, epidemiologic studies indicate that men that develop SLE may
have more morbidity than women, but the same is not true for RA. Given the sex and age
bias of SLE and RA, sex hormones may influence the pathogenesis of these diseases.
However, the ways in which, and to what degree, sex hormones affect disease incidence …