Expressions of short palate, lung and nasal epithelium clone 1 in different human tissues

S Wang, WL Li, LC Lü, KT Yao - Nan Fang yi ke da xue xue bao …, 2016 - europepmc.org
S Wang, WL Li, LC Lü, KT Yao
Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 2016europepmc.org
Objective To examine the expression patterns of short palate, lung and nasal epithelium
clone 1 (SPLUNC1) gene in human tissues. Methods In situ hybridization was used to detect
the expression of SPLUNC1 gene in 37 different human tissues. Results We found that
SPLUNC1 gene was not expressed in squamous epithelial cells of the palate, epidermis,
esophagus, or the esophagus-cardia junction, metaplastic squamous cells in the
nasopharynx, trachea, or uterus cervix, or tumor cells of esophageal squamous cell …
Objective
To examine the expression patterns of short palate, lung and nasal epithelium clone 1 (SPLUNC1) gene in human tissues.
Methods
In situ hybridization was used to detect the expression of SPLUNC1 gene in 37 different human tissues.
Results
We found that SPLUNC1 gene was not expressed in squamous epithelial cells of the palate, epidermis, esophagus, or the esophagus-cardia junction, metaplastic squamous cells in the nasopharynx, trachea, or uterus cervix, or tumor cells of esophageal squamous cell carcinoma or lung squamous cell carcinoma. SPLUNC1 gene was not expressed in the single layer columnar epithelia cells in the stomach, gallbladder, jejunum, colon, endometrium, or uterus cervix. SPLUNC1 expression was detected mainly in pseudostratified columnar epithelial cells in the nasopharynx, trachea and bronchi, and was gradually down-regulated from the upper to lower end of the respiratory tract, but was not detected in the lung tissues. SPLUNC1 expression was detected not only in the duct and serous gland cells in the parotid and submandibular glands, but also in cells of submucosal serous glands in the nasopharynx and lung, but not in the cells of the mucosal glands. The parietal cells of the gastric submucosa and epithelial cells of the lobula and ducts of the mammary glands expressed SPLUNC1. The adenocarcinoma cells in the lung, stomach, colon, mammary gland, uterus endometrium and cervix showed strong expressions of SPLUNC1 gene.
Conclusion
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