[HTML][HTML] Phylogeny of Zika virus in western hemisphere, 2015

RS Lanciotti, AJ Lambert, M Holodniy… - Emerging infectious …, 2016 - ncbi.nlm.nih.gov
RS Lanciotti, AJ Lambert, M Holodniy, S Saavedra, LCC Signor
Emerging infectious diseases, 2016ncbi.nlm.nih.gov
Zika virus was first isolated in 1947 from the blood of a febrile sentinel rhesus monkey during
a study of yellow fever in the Zika Forest of Uganda (1). During the next 20 years, Zika virus
isolates were obtained primarily from East and West Africa during arbovirus surveillance
studies in the absence of epidemics. During those 20 years, cases of Zika virus infection
were detected sporadically; however, given the clinical similarity of Zika and dengue virus
infections and the extensive cross-reactivity of Zika virus antibodies with dengue viruses, it is …
Zika virus was first isolated in 1947 from the blood of a febrile sentinel rhesus monkey during a study of yellow fever in the Zika Forest of Uganda (1). During the next 20 years, Zika virus isolates were obtained primarily from East and West Africa during arbovirus surveillance studies in the absence of epidemics. During those 20 years, cases of Zika virus infection were detected sporadically; however, given the clinical similarity of Zika and dengue virus infections and the extensive cross-reactivity of Zika virus antibodies with dengue viruses, it is possible that Zika virus was associated with epidemics that were incorrectly attributed to dengue viruses. Beginning in 2007, substantial Zika virus outbreaks were reported first in Yap Island (Federated States of Micronesia), then in French Polynesia, and then in other Pacific Islands (2–4). Genetic studies have revealed that Zika virus has evolved into 3 distinct genotypes: West African (Nigerian cluster), East African (MR766 prototype cluster), and Asian. It has been postulated that the virus originated in East Africa and then spread into both West Africa and Asia≈ 50–100 years ago (5). In early 2015, cases of Zika virus infection were detected in Rio Grande State, northern
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