The relationship of photoreceptor degeneration to retinal vascular development and loss in mutant rhodopsin transgenic and RCS rats
ME Pennesi, S Nishikawa, MT Matthes… - Experimental eye …, 2008 - Elsevier
The early loss of photoreceptors in some retinal degenerations in mice has been shown to
have a profound effect on vascular development of the retina. To better characterize this
relationship, we have examined the formation of retinal blood vessels during the first month
of life in 8 lines of transgenic rats with different ages of onset and rates of photoreceptor cell
loss mediated by the expression of mutant rhodopsin (P23H and S334ter). The number of
capillary profiles in the superficial plexus (SP) and deep capillary plexus (DCP) of the retina …
have a profound effect on vascular development of the retina. To better characterize this
relationship, we have examined the formation of retinal blood vessels during the first month
of life in 8 lines of transgenic rats with different ages of onset and rates of photoreceptor cell
loss mediated by the expression of mutant rhodopsin (P23H and S334ter). The number of
capillary profiles in the superficial plexus (SP) and deep capillary plexus (DCP) of the retina …