IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease
J Zepp, L Wu, X Li - Trends in immunology, 2011 - cell.com
J Zepp, L Wu, X Li
Trends in immunology, 2011•cell.comMultiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central
nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is widely used
to dissect molecular mechanisms of MS and to develop new therapeutic strategies. The T
helper 17 (Th17) subset of CD4 T cells plays a crucial role in the development of EAE. IL-17,
a cytokine produced by Th17 cells, participates in EAE pathogenesis through induction of
inflammatory gene expression in target cells. Recent work has shown that Act1, a U-box E3 …
nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is widely used
to dissect molecular mechanisms of MS and to develop new therapeutic strategies. The T
helper 17 (Th17) subset of CD4 T cells plays a crucial role in the development of EAE. IL-17,
a cytokine produced by Th17 cells, participates in EAE pathogenesis through induction of
inflammatory gene expression in target cells. Recent work has shown that Act1, a U-box E3 …
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Experimental autoimmune encephalomyelitis (EAE) is widely used to dissect molecular mechanisms of MS and to develop new therapeutic strategies. The T helper 17 (Th17) subset of CD4 T cells plays a crucial role in the development of EAE. IL-17, a cytokine produced by Th17 cells, participates in EAE pathogenesis through induction of inflammatory gene expression in target cells. Recent work has shown that Act1, a U-box E3 ubiquitin ligase, is recruited to IL-17 receptor (IL-17R) upon IL-17 stimulation and is required for IL-17-mediated signaling. Here, we review the molecular and cellular mechanisms by which IL-17 and Act1-mediated signaling contribute to EAE.
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