The interaction between signal regulatory protein alpha (SIRPα) and CD47: structure, function, and therapeutic target
AN Barclay, TK Van den Berg - Annual review of immunology, 2014 - annualreviews.org
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory
immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member
of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by
CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47
therefore functions as a “don't-eat-me” signal. Here, we discuss recent structural analysis of
CD47-SIRPα interactions and implications of this for the function and evolution of SIRPα and …
immunoreceptor SIRPα (also termed CD172a or SHPS-1). SIRPα is the prototypic member
of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIRPα by
CD47 provides a downregulatory signal that inhibits host cell phagocytosis, and CD47
therefore functions as a “don't-eat-me” signal. Here, we discuss recent structural analysis of
CD47-SIRPα interactions and implications of this for the function and evolution of SIRPα and …
