Bone is a dynamic tissue that is continually undergoing a process of remodeling–an effect
due to the interplay between bone resorption by osteoclasts and bone formation by
osteoblasts. When new bone is deposited, some of the osteoblasts are embedded in the
mineralizing collagen matrix and differentiate to osteocytes, forming a dense network
throughout the whole bone tissue. Here, we investigate the extent to which the organization
of the osteocyte network controls the collagen matrix arrangement found in various bone …