Sarcomere cardiomyopathies are genetic diseases that perturb contractile function and
trigger myocardial remodeling along 2 distinct pathways. Hypertrophic cardiomyopathy
(HCM) exhibits left ventricular (LV) hypertrophy with preserved systolic function and
impaired relaxation. Dilated cardiomyopathy (DCM) is characterized by increased LV
chamber size and systolic dysfunction. The clinical manifestations associated with
sarcomere cardiomyopathies, including age of onset, severity and progression of …