Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases

T Ishizaki, M Uehata, I Tamechika, J Keel… - Molecular …, 2000 - Elsevier
Y-27632 [(+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl) cyclohexanecarboxamide
dihydrochloride] is widely used as a specific inhibitor of the Rho-associated coiled-coil
forming protein serine/threonine kinase (ROCK) family of protein kinases. This study
examined the inhibition mechanism and profile of actions of Y-27632 and a related
compound, Y-30141 [(+)-(R)-trans-4-(1-aminoethyl)-N-(1H-pyrrolo [2, 3-b] pyridin-4-yl)
cyclohexan-ecarboxamide dihydrochloride]. Y-27632 and Y-30141 inhibited the kinase …