Cardiac hypertrophy: the good, the bad, and the ugly
N Frey, EN Olson - Annual review of physiology, 2003 - annualreviews.org
▪ Abstract Cardiac hypertrophy is the heart's response to a variety of extrinsic and intrinsic
stimuli that impose increased biomechanical stress. While hypertrophy can eventually
normalize wall tension, it is associated with an unfavorable outcome and threatens affected
patients with sudden death or progression to overt heart failure. Accumulating evidence from
studies in human patients and animal models suggests that in most instances hypertrophy is
not a compensatory response to the change in mechanical load, but rather is a maladaptive …
stimuli that impose increased biomechanical stress. While hypertrophy can eventually
normalize wall tension, it is associated with an unfavorable outcome and threatens affected
patients with sudden death or progression to overt heart failure. Accumulating evidence from
studies in human patients and animal models suggests that in most instances hypertrophy is
not a compensatory response to the change in mechanical load, but rather is a maladaptive …
