Diabetes and glucose metabolism in thalassemia major: an update

V De Sanctis, AT Soliman, H Elsedfy… - Expert review of …, 2016 - Taylor & Francis
Expert review of hematology, 2016Taylor & Francis
In patients with TM, uncontrolled iron overload has serious clinical consequences with
considerable morbidity and mortality. Complications include liver damage, cardiac disease
and endocrine dysfunction. Diabetes is an important complication of TM. The mechanisms of
abnormal glucose homeostasis are complex and multifactorial. This review updates the
current knowledge about glycemic abnormalities in TM patients and directs the attention to
an early diagnosis and proper management
Abstract
In patients with TM, uncontrolled iron overload has serious clinical consequences with considerable morbidity and mortality. Complications include liver damage, cardiac disease and endocrine dysfunction. Diabetes is an important complication of TM. The mechanisms of abnormal glucose homeostasis are complex and multifactorial. This review updates the current knowledge about glycemic abnormalities in TM patients and directs the attention to an early diagnosis and proper management
Taylor & Francis Online