Depleted leukocyte mitochondrial DNA copy number in metabolic syndrome
CH Huang, SL Su, MC Hsieh, WL Cheng… - … of atherosclerosis and …, 2011 - jstage.jst.go.jp
CH Huang, SL Su, MC Hsieh, WL Cheng, CC Chang, HL Wu, CL Kuo, TT Lin, CS Liu
Journal of atherosclerosis and thrombosis, 2011•jstage.jst.go.jpAims: Metabolic syndrome (MetS) is characterized by a group of defects of metabolic origin
which are possibly involved in mitochondrial DNA (mtDNA) alteration of mtDNA content [Lee
et al. Exp Biol Med, 2007; 232 (5): 592-606]. The present study was undertaken to ascertain
whether alteration of leukocyte mtDNA copy number is related to MetS. Methods: Eighty non-
MetS subjects and 50 subjects with MetS were recruited. The mtDNA copy number of
leukocytes from each group of subjects was measured using quantitative polymerase chain …
which are possibly involved in mitochondrial DNA (mtDNA) alteration of mtDNA content [Lee
et al. Exp Biol Med, 2007; 232 (5): 592-606]. The present study was undertaken to ascertain
whether alteration of leukocyte mtDNA copy number is related to MetS. Methods: Eighty non-
MetS subjects and 50 subjects with MetS were recruited. The mtDNA copy number of
leukocytes from each group of subjects was measured using quantitative polymerase chain …
抄録
Aims: Metabolic syndrome (MetS) is characterized by a group of defects of metabolic origin which are possibly involved in mitochondrial DNA (mtDNA) alteration of mtDNA content [Lee et al. Exp Biol Med, 2007; 232 (5): 592-606]. The present study was undertaken to ascertain whether alteration of leukocyte mtDNA copy number is related to MetS.
Methods: Eighty non-MetS subjects and 50 subjects with MetS were recruited. The mtDNA copy number of leukocytes from each group of subjects was measured using quantitative polymerase chain reaction.
Results: The mtDNA copy number of leukocytes in subjects with MetS was significantly lower than that of non-MetS subjects. Depleted mtDNA copy number is correlated with lower plasma HDL, higher triglyceride, higher HOMA-IR and hypertension, and is even more sensitive to MetS criteria.
Conclusions: Depleted leukocyte mtDNA copy number is related to the severity of MetS. Alteration of mtDNA copy number in leukocytes is proposed as a MetS biomarker involved in the bioenergetic change of mitochondria.
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