Cerebrospinal fluid pharmacokinetics and pharmacodynamics of intrathecal neostigmine methylsulfate in humans
SL Shafer, JC Eisenach, DD Hood… - The Journal of the …, 1998 - pubs.asahq.org
Background This study defines the cerebrospinal fluid (CSF) pharmacokinetics of
neostigmine after intrathecal injection in humans and its effect on CSF acetylcholine, and it
correlates physiologic effects with neostigmine dose and CSF acetylcholine concentrations.
Methods The CSF was sampled via an indwelling spinal catheter in 12 volunteers receiving
intrathecal neostigmine (50-750 microg) and analyzed for neostigmine and acetylcholine.
Pharmacokinetic and pharmacodynamic analyses were performed with NONMEM. Effect …
neostigmine after intrathecal injection in humans and its effect on CSF acetylcholine, and it
correlates physiologic effects with neostigmine dose and CSF acetylcholine concentrations.
Methods The CSF was sampled via an indwelling spinal catheter in 12 volunteers receiving
intrathecal neostigmine (50-750 microg) and analyzed for neostigmine and acetylcholine.
Pharmacokinetic and pharmacodynamic analyses were performed with NONMEM. Effect …