CSF baclofen levels after intrathecal administration in severe spasticity
B Sallerin-Caute, Y Lazorthes, B Monsarrat… - European journal of …, 1991 - Springer
B Sallerin-Caute, Y Lazorthes, B Monsarrat, J Cros, R Bastide
European journal of clinical pharmacology, 1991•SpringerThe pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal
bolus are reported. Considerable inter-individual variability in the parameters was observed.
The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l· h− 1.
In order to optimize treatment, it is suggested that CSF baclofen levels be matched to
changes in Hoffman's monosynaptic reflex (H reflex).
bolus are reported. Considerable inter-individual variability in the parameters was observed.
The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l· h− 1.
In order to optimize treatment, it is suggested that CSF baclofen levels be matched to
changes in Hoffman's monosynaptic reflex (H reflex).
Summary
The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.08 l·h−1.
In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).
Springer
