Effect of intermittent hypoxia on atherosclerosis in apolipoprotein E-deficient mice
J Jun, C Reinke, D Bedja, D Berkowitz, S Bevans-Fonti… - Atherosclerosis, 2010 - Elsevier
OBJECTIVE: Obstructive sleep apnea causes intermittent hypoxia (IH) and is associated
with increased cardiovascular mortality. This increased risk may be attributable to more
extensive or unstable atherosclerotic plaques in subjects with OSA. We studied the effect of
chronic IH in atherosclerosis-prone mice. METHODS AND RESULTS: Apolipoprotein E-
deficient (ApoE−/−) mice fed a high cholesterol diet were exposed to 4 or 12 weeks of IH and
compared to intermittent air-exposed controls. At 4 weeks, IH increased plaque size in the …
with increased cardiovascular mortality. This increased risk may be attributable to more
extensive or unstable atherosclerotic plaques in subjects with OSA. We studied the effect of
chronic IH in atherosclerosis-prone mice. METHODS AND RESULTS: Apolipoprotein E-
deficient (ApoE−/−) mice fed a high cholesterol diet were exposed to 4 or 12 weeks of IH and
compared to intermittent air-exposed controls. At 4 weeks, IH increased plaque size in the …