[HTML][HTML] Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

PE Clavijo, EC Moore, J Chen, RJ Davis, J Friedman… - Oncotarget, 2017 - ncbi.nlm.nih.gov
PE Clavijo, EC Moore, J Chen, RJ Davis, J Friedman, Y Kim, C Van Waes, Z Chen, CT Allen
Oncotarget, 2017ncbi.nlm.nih.gov
Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of
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Abstract
Purpose
Local immunosuppression remains a critical problem that limits clinically meaningful response to checkpoint inhibition in patients with head and neck cancer. Here, we assessed the impact of MDSC elimination on responses to CTLA-4 checkpoint inhibition.
ncbi.nlm.nih.gov