[HTML][HTML] MicroRNA-148a promotes myogenic differentiation by targeting the ROCK1 gene
J Zhang, Z Ying, Z Tang, L Long, K Li - Journal of Biological Chemistry, 2012 - ASBMB
MicroRNAs are evolutionarily conserved small RNAs that post-transcriptionally regulate
gene expression and have emerged as critical regulators of skeletal muscle development.
Here, we identified miR-148a as a novel myogenic microRNA that mediated myogenic
differentiation. The expression levels of miR-148a increased during C2C12 myoblast
differentiation. Overexpression of miR-148a significantly promoted myogenic differentiation
of both C2C12 myoblast and primary muscle cells. Blocking the function of miR-148a with a …
gene expression and have emerged as critical regulators of skeletal muscle development.
Here, we identified miR-148a as a novel myogenic microRNA that mediated myogenic
differentiation. The expression levels of miR-148a increased during C2C12 myoblast
differentiation. Overexpression of miR-148a significantly promoted myogenic differentiation
of both C2C12 myoblast and primary muscle cells. Blocking the function of miR-148a with a …