17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload

RD Patten, I Pourati, MJ Aronovitz, A Alsheikh-Ali… - Journal of cardiac …, 2008 - Elsevier
BACKGROUND: We have shown previously that 17β-estradiol (E2) increases left ventricular
(LV) and cardiomyocyte hypertrophy after myocardial infarction (MI). However, E2 decreases
hypertrophy in pressure overload models. We hypothesized that the effect of estrogen on
cardiac hypertrophy was dependent on the type of hypertrophic stimulus. METHODS AND
RESULTS: Ovariectomized wild-type female mice (n= 192) were given vehicle or E2
treatment followed by coronary ligation (MI), transverse aortic constriction (TAC), or sham …