[HTML][HTML] Splenic differentiation and emergence of CCR5+CXCL9+CXCL10+ monocyte-derived dendritic cells in the brain during cerebral malaria

IC Hirako, MA Ataide, L Faustino, PA Assis… - Nature …, 2016 - nature.com
IC Hirako, MA Ataide, L Faustino, PA Assis, EW Sorensen, H Ueta, NM Araújo, GB Menezes
Nature communications, 2016nature.com
Dendritic cells have an important role in immune surveillance. After being exposed to
microbial components, they migrate to secondary lymphoid organs and activate T
lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes
differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b+ F4/80+
CD11c+ MHCIIhighDC-SIGNhighLy6c+ and express high levels of CCR5, CXCL9 and
CXCL10 (CCR5+ CXCL9/10+ MO-DCs). We propose that malaria-induced splenic MO-DCs …
Abstract
Dendritic cells have an important role in immune surveillance. After being exposed to microbial components, they migrate to secondary lymphoid organs and activate T lymphocytes. Here we show that during mouse malaria, splenic inflammatory monocytes differentiate into monocyte-derived dendritic cells (MO-DCs), which are CD11b+F4/80+CD11c+MHCIIhighDC-SIGNhighLy6c+ and express high levels of CCR5, CXCL9 and CXCL10 (CCR5+CXCL9/10+ MO-DCs). We propose that malaria-induced splenic MO-DCs take a reverse migratory route. After differentiation in the spleen, CCR5+CXCL9/10+ MO-DCs traffic to the brain in a CCR2-independent, CCR5-dependent manner, where they amplify the influx of CD8+ T lymphocytes, leading to a lethal neuropathological syndrome.
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