Regulation and repair of the alveolar-capillary barrier in acute lung injury

J Bhattacharya, MA Matthay - Annual review of physiology, 2013 - annualreviews.org
Considerable progress has been made in understanding the basic mechanisms that
regulate fluid and protein exchange across the endothelial and epithelial barriers of the lung
under both normal and pathological conditions. Clinically relevant lung injury occurs most
commonly from severe viral and bacterial infections, aspiration syndromes, and severe
shock. The mechanisms of lung injury have been identified in both experimental and clinical
studies. Recovery from lung injury requires the reestablishment of an intact endothelial …