Recombinant glycoprotein vaccine for the prevention of genital HSV-2 infection: two randomized controlled trials
L Corey, AGM Langenberg, R Ashley, RE Sekulovich… - Jama, 1999 - jamanetwork.com
ContextIn the last 3 decades, herpes simplex virus type 2 (HSV-2) infection seroprevalence
and neonatal herpes have increased substantially. An effective vaccine for the prevention of
genital herpes could help control this epidemic. ObjectiveTo evaluate the efficacy of a
vaccine for prevention of HSV-2 infection. DesignTwo randomized, double-blind, placebo-
controlled multicenter trials of a recombinant subunit vaccine containing 30 µg each of 2
major HSV-2 surface glycoproteins (gB2 and gD2) against which neutralizing antibodies are …
and neonatal herpes have increased substantially. An effective vaccine for the prevention of
genital herpes could help control this epidemic. ObjectiveTo evaluate the efficacy of a
vaccine for prevention of HSV-2 infection. DesignTwo randomized, double-blind, placebo-
controlled multicenter trials of a recombinant subunit vaccine containing 30 µg each of 2
major HSV-2 surface glycoproteins (gB2 and gD2) against which neutralizing antibodies are …