[PDF][PDF] CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin

S Basu, RJ Binder, T Ramalingam, PK Srivastava - Immunity, 2001 - cell.com
S Basu, RJ Binder, T Ramalingam, PK Srivastava
Immunity, 2001cell.com
Complexes of the heat shock protein gp96 and antigenic peptides are taken up by antigen-
presenting cells and presented by MHC class I molecules. In order to explain the unusual
efficiency of this process, the uptake of gp96 had been postulated to occur through a
receptor, identified recently as CD91. We show here that complexes of peptides with heat
shock proteins hsp90, calreticulin, and hsp70 are also taken up by macrophages and
dendritic cells and re-presented by MHC class I molecules. All heat shock proteins utilize the …
Abstract
Complexes of the heat shock protein gp96 and antigenic peptides are taken up by antigen-presenting cells and presented by MHC class I molecules. In order to explain the unusual efficiency of this process, the uptake of gp96 had been postulated to occur through a receptor, identified recently as CD91. We show here that complexes of peptides with heat shock proteins hsp90, calreticulin, and hsp70 are also taken up by macrophages and dendritic cells and re-presented by MHC class I molecules. All heat shock proteins utilize the CD91 receptor, even though some of the proteins have no homology with each other. Postuptake processing of gp96-chaperoned peptides requires proteasomes and the transporters associated with antigen processing, utilizing the classical endogenous antigen presentation pathway.
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