OLFM4 is a robust marker for stem cells in human intestine and marks a subset of colorectal cancer cells
LG Van der Flier, A Haegebarth, DE Stange… - …, 2009 - gastrojournal.org
The epithelium of the small intestine and colon is the most rapidly self-renewing tissue in
mammals. Proliferative cells are confined to crypts, and differentiated cell types
predominantly occupy the villi in the small intestine and the surface epithelium in the colon.
We recently demonstrated the existence of a long-lived pool of cycling stem cells defined by
Lgr5 expression. These cells are intermingled with postmitotic Paneth cells at crypt bottoms
in the small intestine. In the colon, they reside at crypt bottoms and are intermingled with …
mammals. Proliferative cells are confined to crypts, and differentiated cell types
predominantly occupy the villi in the small intestine and the surface epithelium in the colon.
We recently demonstrated the existence of a long-lived pool of cycling stem cells defined by
Lgr5 expression. These cells are intermingled with postmitotic Paneth cells at crypt bottoms
in the small intestine. In the colon, they reside at crypt bottoms and are intermingled with …