[HTML][HTML] Reactive oxygen species activate p90 ribosomal S6 kinase via Fyn and Ras
J Abe, M Okuda, Q Huang, M Yoshizumi… - Journal of Biological …, 2000 - ASBMB
Reactive oxygen species and growth factors stimulate similar intracellular signal
transduction events including activation of Src kinase family members and extracellular
signal-regulated kinases (ERK1/2). A potentially important downstream effector of Src and
ERK1/2 is p90 ribosomal S6 kinase (p90RSK), which plays an important role in cell growth
by activating several transcription factors as well as the Na+/H+ exchanger. In the present
study, we determined whether H 2 O 2 activates p90RSK to gain insight into signal …
transduction events including activation of Src kinase family members and extracellular
signal-regulated kinases (ERK1/2). A potentially important downstream effector of Src and
ERK1/2 is p90 ribosomal S6 kinase (p90RSK), which plays an important role in cell growth
by activating several transcription factors as well as the Na+/H+ exchanger. In the present
study, we determined whether H 2 O 2 activates p90RSK to gain insight into signal …