[HTML][HTML] Obesity favors apolipoprotein E-and C-III-containing high density lipoprotein subfractions associated with risk of heart disease [S]
Human HDLs have highly heterogeneous composition. Plasma concentrations of HDL with
apoC-III and of apoE in HDL predict higher incidence of coronary heart disease (CHD). The
concentrations of HDL-apoA-I containing apoE, apoC-III, or both and their distribution across
HDL sizes are unknown. We studied 20 normal weight and 20 obese subjects matched by
age, gender, and race. Plasma HDL was separated by sequential immunoaffinity
chromatography (anti-apoA-I, anti-apoC-III, anti-apoE), followed by nondenaturing-gel …
apoC-III and of apoE in HDL predict higher incidence of coronary heart disease (CHD). The
concentrations of HDL-apoA-I containing apoE, apoC-III, or both and their distribution across
HDL sizes are unknown. We studied 20 normal weight and 20 obese subjects matched by
age, gender, and race. Plasma HDL was separated by sequential immunoaffinity
chromatography (anti-apoA-I, anti-apoC-III, anti-apoE), followed by nondenaturing-gel …