Interaction of plasma lipoproteins containing apolipoproteins B and E with heparin and cell surface receptors

RW Mahley, KH Weisgraber, TL Innerarity - Biochimica et Biophysica Acta …, 1979 - Elsevier
Low density lipoproteins (LDL) containing apolipoprotein B and a high density lipoprotein
(the HDL c) containing apolipoprotein E bind to the same cell surface receptors of fibroblasts
and also bind to and are precipitated by heparin. To determine if the nature of the chemical
interaction of these lipoproteins with the receptor and with heparin were identical, we
undertook to compare the effects of the chemical modification of selected amino acid
residues of these lipoproteins on receptor and heparin binding activities. Previously, we …