[HTML][HTML] An activated factor VII variant with enhanced tissue factor‐independent activity speeds wound healing in a mouse hemophilia B model
Essentials• Disorders of hemostasis can lead to delayed and defective wound healing.• In
hemophilia B (HB) mice, 7 days of Factor (F) IX or VIIa are needed to normalize wound
healing.• One dose of a highly active FVIIa variant (DVQ) restored normal wound closure
time in HB mice.• Coagulation factors with enhanced activity may acquire biological effects
not due to hemostasis. Acknowledgements The authors would like to acknowledge the
outstanding technical assistance of J. Brock and A. Crabtree. Novo Nordisk Summary …
hemophilia B (HB) mice, 7 days of Factor (F) IX or VIIa are needed to normalize wound
healing.• One dose of a highly active FVIIa variant (DVQ) restored normal wound closure
time in HB mice.• Coagulation factors with enhanced activity may acquire biological effects
not due to hemostasis. Acknowledgements The authors would like to acknowledge the
outstanding technical assistance of J. Brock and A. Crabtree. Novo Nordisk Summary …