Lipid–protein interactions in blood coagulation
RFA Zwaal, P Comfurius, EM Bevers - Biochimica et Biophysica Acta (BBA) …, 1998 - Elsevier
It has long been appreciated that lipids, particularly anionic phospholipids, promote blood
coagulation. The last two decades have seen an increasing insight into the kinetic and
mechanistic aspects regarding the mode of action of phospholipids in blood coagulation.
This essay attempts to review these developments with particular emphasis on the structure
of lipid-binding domains of blood coagulation proteins, and the variable effect of
phospholipid composition on the interaction with these proteins. Some examples are …
coagulation. The last two decades have seen an increasing insight into the kinetic and
mechanistic aspects regarding the mode of action of phospholipids in blood coagulation.
This essay attempts to review these developments with particular emphasis on the structure
of lipid-binding domains of blood coagulation proteins, and the variable effect of
phospholipid composition on the interaction with these proteins. Some examples are …