[HTML][HTML] CD40-independent help by memory CD4 T cells induces pathogenic alloantibody but does not lead to long-lasting humoral immunity
M Rabant, V Gorbacheva, R Fan, H Yu… - American Journal of …, 2013 - Elsevier
CD40/CD154 interactions are essential for productive antibody responses to T-dependent
antigens. Memory CD4 T cells express accelerated helper functions and are less dependent
on costimulation when compared with naïve T cells. Here, we report that donor-reactive
memory CD4 T cells can deliver help to CD40-deficient B cells and induce high titers of IgG
alloantibodies that contribute to heart allograft rejection in CD40−/− heart recipients. While
cognate interactions between memory helper T and B cells are crucial for CD40 …
antigens. Memory CD4 T cells express accelerated helper functions and are less dependent
on costimulation when compared with naïve T cells. Here, we report that donor-reactive
memory CD4 T cells can deliver help to CD40-deficient B cells and induce high titers of IgG
alloantibodies that contribute to heart allograft rejection in CD40−/− heart recipients. While
cognate interactions between memory helper T and B cells are crucial for CD40 …