Antibody-mediated lymphocyte depletion is frequently used as induction therapy in
sensitized transplant patients. Although T cells with an effector/memory phenotype remain
detectable after lymphoablative therapies in human transplant recipients, the role of
preexisting donor-reactive memory in reconstitution of the T cell repertoire and induction of
alloimmune responses following lymphoablation is poorly understood. We show in a mouse
cardiac transplantation model that antidonor immune responses following treatment with …