Humanized mouse models of clinical disease
NC Walsh, LL Kenney, S Jangalwe… - Annual Review of …, 2017 - annualreviews.org
NC Walsh, LL Kenney, S Jangalwe, KE Aryee, DL Greiner, MA Brehm, LD Shultz
Annual Review of Pathology: Mechanisms of Disease, 2017•annualreviews.orgImmunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study
of human diseases. Since the description of immunodeficient mice bearing mutations in the
IL2 receptor common gamma chain (IL2rgnull) in the early 2000s, investigators have been
able to engraft murine recipients with human hematopoietic stem cells that develop into
functional human immune systems. These mice can also be engrafted with human tissues …
mice, have become increasingly important as small, preclinical animal models for the study
of human diseases. Since the description of immunodeficient mice bearing mutations in the
IL2 receptor common gamma chain (IL2rgnull) in the early 2000s, investigators have been
able to engraft murine recipients with human hematopoietic stem cells that develop into
functional human immune systems. These mice can also be engrafted with human tissues …
Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized mice, have become increasingly important as small, preclinical animal models for the study of human diseases. Since the description of immunodeficient mice bearing mutations in the IL2 receptor common gamma chain (IL2rgnull) in the early 2000s, investigators have been able to engraft murine recipients with human hematopoietic stem cells that develop into functional human immune systems. These mice can also be engrafted with human tissues such as islets, liver, skin, and most solid and hematologic cancers. Humanized mice are permitting significant progress in studies of human infectious disease, cancer, regenerative medicine, graft-versus-host disease, allergies, and immunity. Ultimately, use of humanized mice may lead to the implementation of truly personalized medicine in the clinic. This review discusses recent progress in the development and use of humanized mice and highlights their utility for the study of human diseases.
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