Sleeve gastrectomy leads to weight loss in the Magel2 knockout mouse
Abstract Background Prader-Willi syndrome (PWS) is a genetic disorder characterized by
hyperphagia, obesity, cardiopulmonary diseases, and increased mortality. Although
successful weight loss improves health in PWS, few treatments cause sustained weight loss
in obese patients let alone obese individuals with PWS. Objectives The present study uses
the Magel2 knockout (KO) mouse, an animal model of PWS, to conduct a preclinical study
on the efficacy of sleeve gastrectomy (SG) in PWS. Setting Academic research laboratory …
hyperphagia, obesity, cardiopulmonary diseases, and increased mortality. Although
successful weight loss improves health in PWS, few treatments cause sustained weight loss
in obese patients let alone obese individuals with PWS. Objectives The present study uses
the Magel2 knockout (KO) mouse, an animal model of PWS, to conduct a preclinical study
on the efficacy of sleeve gastrectomy (SG) in PWS. Setting Academic research laboratory …