MicroRNA-196a/b mitigate renal fibrosis by targeting TGF-β receptor 2

J Meng, L Li, Y Zhao, Z Zhou, M Zhang… - Journal of the …, 2016 - journals.lww.com
Organ-specific microRNAs have essential roles in maintaining normal organ function.
However, the microRNA profile of the kidney and the role of microRNAs in modulating renal
function remain undefined. We performed an unbiased assessment of the genome-wide
microRNA expression profile in 14 mouse organs using Solexa deep sequencing and found
that microRNA-196a (miR-196a) and miR-196b are selectively expressed in kidney, with
74.37% of mouse total miR-196a and 73.19% of mouse total miR-196b distributed in the …