[HTML][HTML] Versican: a novel modulator of hepatic fibrosis

TN Bukong, SB Maurice, B Chahal, DF Schaeffer… - Laboratory …, 2016 - Elsevier
Little is known about the deposition and turnover of proteoglycans in liver fibrosis, despite
their abundance in the extracellular matrix. Versican plays diverse roles in modulating cell
behavior in other fibroproliferative diseases, but remains poorly described in the liver.
Hepatic fibrosis was induced by carbon tetrachloride treatment of C57BL/6 mice over 4
weeks followed by recovery over a 28-day period. Primary mouse hepatic stellate cells
(HSCs) were activated in culture and versican was transiently knocked down in human …