[HTML][HTML] Regulation of the versican promoter by the β-catenin-T-cell factor complex in vascular smooth muscle cells
M Rahmani, JT Read, JM Carthy, PC McDonald… - Journal of Biological …, 2005 - ASBMB
The proteoglycan versican is pro-atherogenic and central to vascular injury and repair
events. We identified the signaling pathways and promoter elements involved in regulation
of versican expression in vascular smooth muscle cells. Phosphatidylinositol 3-kinase
inhibitor, LY294002, significantly decreased versican-luciferase (Luc) promoter activity and
endogenous mRNA levels. We further examined the roles of protein kinase B and glycogen
synthase kinase (GSK)-3β, downstream effectors of phosphatidylinositol 3-kinase, in the …
events. We identified the signaling pathways and promoter elements involved in regulation
of versican expression in vascular smooth muscle cells. Phosphatidylinositol 3-kinase
inhibitor, LY294002, significantly decreased versican-luciferase (Luc) promoter activity and
endogenous mRNA levels. We further examined the roles of protein kinase B and glycogen
synthase kinase (GSK)-3β, downstream effectors of phosphatidylinositol 3-kinase, in the …