CD44 deficiency increases tubular damage but reduces renal fibrosis in obstructive nephropathy
KMA Rouschop, ME Sewnath, N Claessen… - Journal of the …, 2004 - journals.lww.com
CD44 is a glycoprotein involved in inflammation and cell-cell/cell-matrix interactions. CD44
is upregulated in the kidney upon injury; however, its role in the pathogenesis of renal
damage and fibrosis remains largely unknown. The authors show that mice lacking CD44
developed more tubular damage, associated with decreased proliferation and increased
apoptosis of tubular epithelial cells, but less renal fibrosis after unilateral ureteral
obstruction. In addition, impaired influx of macrophages and decreased accumulation of …
is upregulated in the kidney upon injury; however, its role in the pathogenesis of renal
damage and fibrosis remains largely unknown. The authors show that mice lacking CD44
developed more tubular damage, associated with decreased proliferation and increased
apoptosis of tubular epithelial cells, but less renal fibrosis after unilateral ureteral
obstruction. In addition, impaired influx of macrophages and decreased accumulation of …