Imaging lymphoid tissues in nonhuman primates to understand SIV pathogenesis and persistence
Highlights•NHP research provides a vital bridge between basic/preclinical research and
clinical studies.•Imaging approaches of SIV NHP models afford unique insights into HIV-1
infection and disease.•NHP models provided direct and unequivocal evidence that GI tract
damage leads to systemic immune activation.•Lymphoid tissue fibrosis is a hallmark
pathological feature of lentiviral infections.•B cell follicles are important tissue sites for viral
persistence during cART.CD4+ T cells are the primary HIV-1 target cell, with the vast …
clinical studies.•Imaging approaches of SIV NHP models afford unique insights into HIV-1
infection and disease.•NHP models provided direct and unequivocal evidence that GI tract
damage leads to systemic immune activation.•Lymphoid tissue fibrosis is a hallmark
pathological feature of lentiviral infections.•B cell follicles are important tissue sites for viral
persistence during cART.CD4+ T cells are the primary HIV-1 target cell, with the vast …
