Still NAAG'ing after all these years: the continuing pursuit of GCPII inhibitors
JJ Vornov, KR Hollinger, PF Jackson… - Advances in …, 2016 - Elsevier
Nearly two decades ago, Joe Coyle published a single-authored review with the provocative
title, The Nagging Question of the Function of N-Acetylaspartylglutamate (Coyle, 1997). In
this review, Coyle documented NAAG's localization to subpopulations of glutamatergic,
cholinergic, GABAergic, and noradrenergic neurons, Ca 2+-dependent release, mGlu3
receptor agonist and NMDA receptor antagonist activity, and cleavage by the glial enzyme
glutamate carboxypeptidase II (GCPII). However, at the time of his review, NAAG's …
title, The Nagging Question of the Function of N-Acetylaspartylglutamate (Coyle, 1997). In
this review, Coyle documented NAAG's localization to subpopulations of glutamatergic,
cholinergic, GABAergic, and noradrenergic neurons, Ca 2+-dependent release, mGlu3
receptor agonist and NMDA receptor antagonist activity, and cleavage by the glial enzyme
glutamate carboxypeptidase II (GCPII). However, at the time of his review, NAAG's …