Glutamate transporters GLAST and EAAT4 regulate postischemic Purkinje cell death: an in vivo study using a cardiac arrest model in mice lacking GLAST or EAAT4
A Yamashita, K Makita, T Kuroiwa, K Tanaka - Neuroscience research, 2006 - Elsevier
Cerebellar Purkinje cells represent a group of neurons highly vulnerable to ischemia.
Excitotoxicity is thought to be an important pathophysiological mechanism in Purkinje cell
death following ischemia. The glutamate transporter is the only mechanism for the removal
of glutamate from the extracellular fluid in the brain. Therefore, glutamate transporters are
believed to play a critical role in protecting Purkinje cells from ischemia-induced damage.
Two distinct glutamate transporters, GLAST and EAAT4, are expressed most abundantly in …
Excitotoxicity is thought to be an important pathophysiological mechanism in Purkinje cell
death following ischemia. The glutamate transporter is the only mechanism for the removal
of glutamate from the extracellular fluid in the brain. Therefore, glutamate transporters are
believed to play a critical role in protecting Purkinje cells from ischemia-induced damage.
Two distinct glutamate transporters, GLAST and EAAT4, are expressed most abundantly in …